Director, Commercial Development

Madrigal is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a serious liver disease that can progress to cirrhosis, liver failure, need for liver transplantation and premature mortality. Every member of our Madrigal team is connected by our shared purpose: leading the fight against MASH. Madrigal’s medication, Rezdiffra (resmetirom), is a once-daily, oral, liver‑directed THR‑β agonist designed to target key underlying causes of MASH.

Rezdiffra is the first and only medication approved by both the FDA and European Commission for the treatment of MASH with moderate to advanced fibrosis (F2 to F3). An ongoing Phase 3 outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (F4c). Our success is driven by our people.

We are building a dynamic, inclusive, and high‑performing culture that values scientific excellence, operational rigor, and collaboration. To support our continued growth, we are strengthening our workforce strategy to ensure we have the right talent, at the right time, in the right way. Position Overview The Director, Commercial Development will be a critical member of the US Marketing and Commercial organizations who will help build the future of Madrigal.

This is a unique opportunity to make a difference for the betterment of patients living with MASH. This individual will be responsible for representing the global commercial perspective across the Madrigal pipeline, ensuring development, commercialization strategy, and launch planning reflect and are fully aligned to commercial priorities. The role serves as a key stakeholder interfacing with study and program teams, providing strategic guidance on target product profiles (TPP), market positioning, clinical development prioritization, and commercial readiness to maximize portfolio value.

The Director will work cross‑functionally with RD, Medical Affairs, Market Access, Commercial Strategy and Regulatory to shape the development path and commercialization strategy. The role requires deep expertise in specialty pharma market dynamics, competitive intelligence, payer landscape, and commercial strategy, to provide insightful feedback and inform global decisions from early development through launch and lifecycle management. Clinical development & indication strategy Provide commercial input on indication prioritization, endpoints, comparator strategy, and trial design.

Identify label‑optimizing opportunities and evidence needs to support global approval, access and adoption. Market intelligence & competitive strategy Support market landscape and market research analyses: epidemiology, treatment pathways, competitive pipelines and emerging modalities. Partner with Commercial Strategy & Operations, Medical Affairs and Thought Leadership team to surface signals that drive strategic shifts.

Forecasting & business planning Collaborate on revenue forecasting, scenario planning and pricing/market uptake assumptions. Inform investment, launch sequencing and lifecycle decisions with commercial assessments. Support cross‑functional commercialization planning with Sales, Marketing, Market Access, Patient Access, Thought Leadership, Communications and Medical Affairs for coordinated launch readiness and market shaping.

Leadership competencies This role ensures the product is developed and positioned to achieve maximum clinical adoption and commercial success in the U.S. market by embedding U.S. evidence, access and commercialization needs into global development and launch decisions. Key Skills/Requirements Proactive, self‑starter and independent worker motivated by challenges and delivering results (business owner mindset) Strategic thinker with strong commercial acumen and ability to balance near‑term development priorities with long‑term asset value High learning agility and problem‑solving skills with ability to multi‑task across several projects Data‑driven decision maker with strong analytical skills to quickly diagnose problems and develop fit‑for‑purpose solutions Ability to influence without formal authority to drive cross‑functional alignment Ability to execute and thrive in fast‑paced environments filled with ambiguity Superb communication skills, both verbal and written Desire to professionally develop and gain more responsibilities resulting in greater impact Limited travel—up to 25% of the time (including weekends as needed) Required to be in office 3 days per week (Conshohocken, PA or Waltham, MA) Education/Experience Bachelor’s Degree required, advanced degree preferred 12‑15+ years of biopharmaceutical marketing and/or commercial development experience Must have direct commercial development experience working on assets across the product lifecycle, in particular, from pre‑commercialization to launch Experience with MASH or related therapeutic areas is a plus Strong scientific background is a plus Experience in smaller company (or team) environments is a plus Compensation and Benefits Madrigal’s Total Rewards strategy is based on a biotech industry peer group comparator and is inclusive of base pay, bonus and equity. Our equity offers meaningful opportunity allowing our employees to share in the success they help create.

By aligning individual and company performance, we empower employees to think like owners, giving them a stake in the organization. Base salary is determined by several factors including the candidate’s qualifications, skills, education, experience, business needs and market demands. As of the date of this posting, a good faith estimate of the current pay scale for this position, applicable to all candidates, is $214,000–$261,000 per year.

We comply with all applicable minimum wage laws. Full‑time employees are also eligible for comprehensive benefits, including flexible paid time off, medical, dental, vision and life/disability insurance, and 401(k) offerings (traditional, Roth, and employer match) in accordance with applicable plans. We also offer additional voluntary benefits like supplemental life insurance, legal services, and other offerings.

In addition, we offer mental health benefits through our Employee Assistance Program for employees and their family. EEO Statement Madrigal is an Equal Opportunity Employer. All employment is decided on the basis of qualifications, merit, and business need.

Applicants will receive consideration for employment without regard to race, ethnicity, color, religion, sex, gender identity, sexual orientation, national origin, age, disability, protected veteran or disabled status, or other characteristic protected by applicable federal, state, or local law. #J-18808-Ljbffr